Table 3.

Evaluation of the independent effects of EASIX, ferritin, and CRP levels on ICANS grades 2 to 4

	Parameters
Risk groups	Ferritin	EASIX/CRP	n*	Events, n	CumInc, % (range)	HR	95% CI	P
High risk	High	Any level	35	26	74	3.6	1.9-6.9	<.001
Intermediate risk	Low	High EASIX or	41	21	51 (38-69)	2.1	1.1-3.9	.025
		High CRP	19	10	53 (34-81)
Low risk	Low	Low EASIX, and low CRP	45	13	29 (18-46)	1.0	—	—

High ferritin, levels in the upper quartile (ferritin >1583 ng/mL); high EASIX, levels above the median (>2.1); high CRP, levels above the median (>21 mg\L).

High- vs intermediate-risk groups: HR, 1.8; 95% CI 1.1-2.9; P = 0.03; high EASIX vs high CRP within intermediate-risk groups: HR, 0.9; 95% CI, 0.4-1.9, P = 0.8.

CumInc, cumulative incidence; HR, hazard ratio; CI, confidence interval.

*Only patients with available ferritin levels were eligible for this analysis.