Figure 1.

DNA-methylation levels in JMML BM granulocytes during treatment with azacitidine. (A) GDMS for all CpG probes with β ≥0.75 at predose on C1D1. (B) JDMS derived from differentially methylated probes (JMML DMPs) across all time points. Data illustrated as absolute values or relative change. Statistics performed via Kruskal-Wallis one-way analysis of variance/Dunn test. Significance vs C1D1: *P < .05; **P < .01; ***P < .001; ****P < .0001. C, cycle; D, day; NR, nonresponder; R, responder.