Fig. 3. Small molecule scaffolds for prolonging in vivo half-life or cell permeability of peptides. (a) Stable maleimide modified version of Evans blue dye with high affinity for serum albumin. (b) Dicoumarol maleimide-based tag for enhancing the in vivo half-life of Glucagon like peptide-1 analogues. (c) Divalent albumin binding tag comprised of Diflunisal and Indomethacin. (d) Transthyretin-binding small molecule ligand for improving the in vivo half-life of Gonadotropin-releasing hormone. (e) Oxadiazole-containing cyclic peptide displaying higher passive membrane permeability compared to its homodetic counterpart. Small molecule components are highlighted in red.
