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. 2021 Aug 5;16(8):e0255230. doi: 10.1371/journal.pone.0255230

Table 3. Odds ratios for mortality according to the peak bilirubin level.

N Hospital mortality (%) Crude OR (95% CI) Model 1 OR (95% CI) Model 2 OR (95% CI)
Peak bilirubin value (mg/dL) 1.062 (1.025–1.099) 1.075 (1.029–1.124) 1.093 (1.042–1.147)
Peak bilirubin grade
1 (12~15) 111 62.2 Reference Reference Reference
2 (15~20) 99 71.7 1.543 (0.759–3.141) 1.657 (0.734–3.742) 1.921 (0.699–5.280)
3 (20~30) 131 81.7 2.714 (1.327–5.549) 3.350 (1.493–7.520) 3.548 (1.328–9.478)
4 (30~) 86 90.7 5.935 (2.174–16.203) 8.315 (2.761–25.035) 12.472 (3.074–50.592)

OR: odds ratio; CI, confidence interval.

Chronic liver disease: liver cirrhosis, chronic viral hepatitis, alcoholic liver disease, autoimmune hepatitis, drug-induced and toxic hepatitis.

Model 1, multivariable logistic analysis with sex, age, body mass index (BMI), medical history (alcohol drinking, smoking, diabetes mellitus, hypertension, dyslipidemia, chronic liver disease, obstructive jaundice, cancer, hepatic encephalopathy, disseminated intravascular coagulation (DIC), acute on chronic liver failure (ACLF), ischemic heart disease, stroke, hypoxic hepatitis, sepsis, and shock); Model 2, multivariable logistic analysis with sex, age, BMI, medical history (same as model 1), cardio-pulmonary resuscitation (CPR), extracorporeal membrane oxygenation (ECMO), liver surgery, ursodeoxycholic acid (UDCA), the initial Sequential Organ Failure Assessment (SOFA) score, number of dysfunctional organs, laboratory results, and type of hyperbilirubinemia.