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. 2021 Jul 22;12:712556. doi: 10.3389/fimmu.2021.712556

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Copyright © 2021 Zhu, Tang, Zhan, Su and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PARPs regulate cGAS-STING-mediated innate immune responses. PARP1, PARP2, and PARP3 participate in the DNA repair process upon the DNA damage response (DDR) caused by DNA double-strand breaks (DSB) or DNA single-strand breaks (SSB). The treatment of PARP inhibitor (PARPi) prevents DNA repair, resulting in the accumulation of damaged DNA, which is recognized by cyclic GMP-AMP (cGAMP) synthase (cGAS) in the cytoplasm. The induction of type I interferon (IFN-I) is mediated by cAMP-STING-IRF3/NF-κB signaling pathway.