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. 2021 Aug 5;16(8):e0254421. doi: 10.1371/journal.pone.0254421

Fig 6. Class-switched memory B-cell (CS-Bmem) responses in young and elderly participants vaccinated for three consecutive years.

Fig 6

A) Representative gating strategy to quantify rHA-specific CS-Bmem in the peripheral blood of vaccinated participants. B) Percentage of vaccine-specific and historical-specific CS-Bmem in the peripheral blood of young (red) and elderly (blue) vaccinated participants. C-E) Percentage of vaccine-specific (C), historical-specific (D) and broadly-reactive (E) CS-Bmem in young (red) and elderly (blue) participants vaccinated for three consecutive years. Lines show cubic spline interpolation model for young adult (red) and elderly (blue) participants. F-H) Percentage of H1N1 and H3N2 vaccine-specific (F), historical-specific (G), and broadly reactive (H) CS-Bmem in young adult(red) and elderly participants vaccinated for three consecutive years I) Bmem-derived IgG antibodies against rHA from current vaccine strain and historical seasonal virus strains, as in Figs 4 and 5, in three young adult (red) and three elderly (blue) participants vaccinated for three consecutive years.