Table 1. Transmission of WTD isolates in different rodent models.
| Animal model | Passage | CWD isolates (mean survival time in days ± SD) | Comments | |||
|---|---|---|---|---|---|---|
| Wisc-1 | 116AG | H95+ | ||||
| short | long | |||||
| tg1536 | 1st | 241 ± 20 (9/9) a | 301 ± 26 (10/10) a | - | a Data published in (Hannaoui, Amidian et al. 2017) | |
| 2nd | 248 ± 26 (5/5) a | 213 ± 38 (5/5) a | - | a Data published in (Hannaoui, Amidian et al. 2017) | ||
| 3rd | 170 ± 23 (5/5) | 199 ± 7 (5/5) | 229 ± 11 (5/5) | - | 116AG-short and -long have been inoculated separately | |
| 4th | 188 ± 28 (5/5) | 226 ± 19 (5/5) | 227 ± 30 (5/5) | - | ||
| tg60 | 1st | > 600 (0/10) b | 634 ± 40 (14/14) | 485 ± 5 (5/5) | b Data published in (Velasquez, Kim et al. 2015) | |
| Bank Vole | 1st | 300 ± 52 (3/5) * | > 700 (0/6) | - | * Two voles had died from intercurrent disease at 100 dpi and have been tested negative in RT-QuIC and western blot | |
| 2nd | 146 ± 15 (6/6) | - | - | |||
| Syrian Golden hamsters | 1st | 652.6 ±.5 (3/8) c and ** | 638 (1/12) *** | - |
c Data published in (Herbst, Velasquez et al. 2017) ** 3/8 animals displayed clinical signs prior to experimental endpoint ** 8/8 animals were PrPres positive ➔All animals had migration pattern at 21 kDa (classic) *** 1/12 animals displayed clinical signs prior to experimental endpoint *** 10/12 animals were PrPres positive ➔ 7/10 had migration pattern at 21 kDa (classic) ➔ 3/10 had migration pattern at 20 kDa (low) |
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