Table 1. Model physical and computational parameters.

Physical parameters	Value	References
Tumor cell diameter	2RT = 15 μm	[16,17]
Stromal cell diameter	2RS = 7.5 μm	[18]
Vessel diameter	2RV = 40 μm	[19]
Force stiffness	$\mathcal{F}=50\mu g/\mu m\bullet s^2$	[20,21]
Medium viscosity	ν = 250 μg/μm∙s	[22]
Oxygen diffusion	${\mathcal{D}}_{\gamma }=100{\mu m}^2/s$	[23,24]
Vascular level of oxygen	γmax = 60 σg/μm3[60 mmHg]	[6,19,25]
Michaelis constant	κm = 134 σg/μm3	[26]
Tumor base oxygen uptake rate	Tmax = 0.382 σg/s * cell volume	[26]
Stromal base oxygen uptake rate	Smax = 0.382 σg/s * cell volume	[26]
Influx rate	0≤δV(t)≤1
Uptake rate	0≤δT(t)≤50
Computational parameters
Domain size	Ω = [−500,500]×[−500,500] μm2
Grid width	Δx = 5 μm
Time step	Δt = 0.05 s
Scaling parameter	σg = 0.5×10−19g = 0.05 ag