TABLE 3.
White matter tracts with significant differences in FA and RD between future responders and non-responders to paroxetine treatment after controlling for age, sex, and time between assessments.
| WM tract |
MNI coordinates at signal peak |
Cluster size | p-values (FWE corrected) | ||
| x | y | z | |||
| FA: responders > non-responders | |||||
| Forceps minor | −15 | 1 | 30 | 2,601 | 0.015 |
| Forceps minor | 20 | 40 | 11 | 1,445 | 0.024 |
| L superior longitudinal fasciculus | −34 | −65 | 26 | 2,306 | 0.018 |
| L superior longitudinal fasciculus | −29 | 7 | 40 | 166 | 0.042 |
| L inferior fronto-occipital fasciculus | −29 | 12 | −1 | 190 | 0.042 |
| R superior longitudinal fasciculus | 35 | 16 | 28 | 124 | 0.048 |
| RD: responders < non-responders | |||||
| L superior longitudinal fasciculus | −31 | −60 | 33 | 269 | 0.041 |
The WM tracts were identified using the Johns Hopkins University WM Tractography atlas.L, left; R, right; WM, white matter; MNI, Montreal Neurological Institute; FWE, family wise error, FA, Fractional anisotropy; RD, radial diffusivity. p < 0.05 (FWE corrected), K > 50.