Determination of the kinetic parameters K_I, k_inact, k_inact/K_I^a.

Compound	K I [nM]	k inact [min−1]	k inact/KI [μM−1 s−1]
JS25	0.32 ± 0.05	0.378 ± 0.034	19.4 ± 1.55
JS26	1.93 ± 0.18	0.443 ± 0.003	3.86 ± 0.34
JS24	2.52 ± 0.01	0.335 ± 0.001	2.22 ± 0.01
JS27	2.15 ± 0.13	0.166 ± 0.003	1.29 ± 0.10
BMX-IN-1	4.07 ± 0.06	0.217 ± 0.005	0.89 ± 0.20b

^aResults tested in duplicate, showing mean ± S.D.

^bValue with a 0.06 μM⁻¹ s⁻¹ deviation from published results.³⁸