Gene cluster comparison of aureolic acid biosynthesis genes: homologous genes between the metathramycin (MMY), mithramycin (MTM) and chromomycin A3 (CMM) biosynthetic gene clusters are indicated, with percentage amino acid identities of Mmy proteins to Mtm and Cmy proteins, respectively.
| Metathramycin BGC | Mithramycin BGC | Chromomycin A3 BGC | Proposed function | % aa identity (Mmy:Mtm/Cmm) |
|---|---|---|---|---|
| CmmA | O-acyltransferase | |||
| MtmA | AdoMet synthetase | |||
| MmyC | MtmC | CmmC | NDP-C-methyltransferase | 72.7/39.5 |
| MmyD | MtmD | CmmD | NDP-glucose synthase | 53.8/53.0 |
| MmyE | MtmE | CmmE | NDP-4,6-dehydratase | 63.4/65.8 |
| CmmF | NDP-5-epimerase | |||
| MmyGI | MtmGI | CmmGI | Glycosyltransferase | 57.1/38.9 |
| MmyGII | MtmGII | CmmGII | Glycosyltransferase | 58.4/42.2 |
| MmyGIII | MtmGIII | CmmGIII | Glycosyltransferase | 66.9/46.0 |
| MmyGIV | MtmGIV | CmmGIV | Glycosyltransferase | 67.6/47.7 |
| MmyH | MtmH | Adenosylhomocysteinase | 90.1/ | |
| MmyHy | Hydrolase | |||
| MmyK | MtmK | CmmK | Ketosynthase β | 63.5/64.4 |
| CmmLI | Acyl-CoA ligase | |||
| MmyL | MtmL | CmmLII | Acyl-CoA ligase | 48.3/53.8 |
| MmyMI | MtmMI | CmmMI | O-methyltransferase | 56.1/55.1 |
| MmyMII | MtmMII | CmmMII | C-methyltransferase | 50.3/54.2 |
| CmmMIII | O-methyltransferase | |||
| MmyOI | MtmOI | CmmOI | Oxygenase | 54.1/56.8 |
| MmyOII | MtmOII | CmmOII | Oxygenase | 51.6/53.5 |
| MtmOIII | Oxygenase | |||
| MmyO3 | Oxygenase | |||
| MmyOIV | MtmOIV | CmmOIV | Oxygenase | 63.3/57.2 |
| MmyP | MtmP | CmmP | Ketosynthase α | 67.6/71.9 |
| MmyQ | MtmQ | CmmQ | Aromatase | 50.2/55.9 |
| MmyRI | MtmR | CmmRI | Transcriptional activator | 41.7/41.6 |
| MmyRII | MtrY | CmmRII | Regulator | 67.4/23.7 |
| MmyRIII | Regulator | |||
| MmyS | MtmS | CmmS | Acyl carrier protein | 41.3/49.3 |
| MmyTI | MtmTI | CmmTI | Ketoreductase | 50.2/52.3 |
| MmyTII | MtmTII | CmmTII | Ketoreductase | 58.5/57.3 |
| MmyTIII | MtmTIII | NDP-4-ketoreductase | 63.4/ | |
| CmmUI | NDP-4-ketoreductase | |||
| CmmUII | NDP-4-ketoreductase | |||
| CmmUIII | NDP-4-ketoreductase | |||
| MmyV | MtmV | CmmV | NDP-2,3-dehydratase | 61.3/46.2 |
| MmyU | MtmU | CmmW | NDP-3-ketoreductase | 64.0/52.5 |
| MmyW | MtmW | CmmWI | Ketoreductase | 75.1/65.4 |
| MmyX | MtmX | CmmX | Cyclase | 52.6/57.0 |
| MmyY | MtmY | CmmY | Cyclase | 67.7/70.4 |
| MtmZ | Thioesterase | |||
| MmrAI | MtrA | CmrA | ATP-binding protein | 66.3/52.9 |
| MmrAII | ATP-binding protein | |||
| MmrBI | MtrB | CmrB | Membrane protein | 62.4/48.8 |
| MmrBII | Membrane protein | |||
| MmrX | MtrX | CmrX | UV-repair system | 63.6/54.0 |