Kinetic parameters for covalent inhibition of HiCel7B by putative β-1,4-glucanase inhibitors.
| Compound | HiCel7B | ||
|---|---|---|---|
| K I (μM) | k inact (min−1) | k inact/KI (s−1 M−1) | |
| 1 | 31 ± 4 | 0.84 ± 0.08 | 450 |
| 5 | 1.9 ± 0.3 | 0.35 ± 0.03 | 3100 |
| 13 | 3.9 ± 0.3 | 0.50 ± 0.03 | 2100 |
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