. 2021 Jun 21;2(4):1158–1166. doi: 10.1039/d1cb00110h

Summary of candidate therapeutics directly targeting TDP-43.

Name	Therapeutic type	Targeted site	Cell	Fly	Mice
3B12A	Antibody	Misfolded RRM2	Clearance of pathological TDP-43 in HEK293A cells	N/A	Clearance of TDP-43 aggregates in newborn mice transduced with TDP-43^{mNLS,C173S/C175S}
VH7Vk9	Antibody	Misfolded RRM1	Induced proteasome and autophagy-driven degradation of TDP-43 in HEK293 cells	N/A	Improved cognitive function in TDP-^43G348C mice
Liu “A, B, C, D, E”	Peptide	CTD	Reduced aggregation of TDP-43 in HeLa cells but not toxicity	N/A	N/A
Gao “D4”	Peptide	CTD	Reduced TDP-43 levels in an N2a cell line overexpressing TDP-43	Recapitulated in Drosophila overexpressing TDP-43	N/A
AIM4	Small molecule	CTD	Reduced TDP-43 inclusions in a yeast S. cerevisiae model	N/A	N/A
rTRD01	Small molecule	RRM1/2	N/A	ALS Drosophila model results in reduced locomotor defects	N/A
nTRD22	Small molecule	NTD	Reduced TDP-43 protein levels in rodent primary motor neurons	Mitigated motor impairment in Drosophila model of ALS	N/A