Fig. 3. Pressure dependent smFRET E-histogram and population distribution of the open (E ≈0.9) and closed (E ≈ 0.3) conformation of the DNA Hp (∼50 pM) in 20 mM Tris HCl, pH 7.5, and 15 mM NaCl at 25 °C (A and B). The samples further contained (C) 100 μM α-Syn monomers, (D) 100 μM α-Syn monomers + 1 M TMAO, (E) 100 μM α-Syn aggregates, and (F) 100 μM α-Syn aggregates + 1 M TMAO.
