Pressure-induced volume change of the conformational transitions of the hTel i-motif and DNA Hp under different solution conditions. ΔV was calculated from the pressure dependence of the equilibrium constant, dln K/dp = −ΔV/(RT), of the relative population distributions via linear regression.

Sample	ΔV/cm3 mol−1
hTel i-motif in 100 μM α-Syn aggregate	−54 ± 10
DNA Hp in buffer	−26 ± 2
DNA Hp in 1 M TMAO	−12 ± 3
DNA Hp in 100 μM monomeric α-Syn	−18 ± 1
DNA Hp in 100 μM monomeric α-Syn + 1 M TMAO	−19 ± 3
DNA Hp in 100 μM aggregated α-Syn	−14 ± 2
DNA Hp in 100 μM aggregated α-Syn + 1 M TMAO	∼0