Fig. 3. Pharmaceutical disruption of the Mdm2–p53 PPI. (A) Schematic of p53 stabilization by a small molecule inhibitor. (B) Nutlin-3 and RG7112 structures. (C) Nutlin-3 (cyan) (PDB: 4J3E) and RG7112 (yellow) (PDB: 4IPF) in complex with the p53 binding site of Mdm2.