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. 2021 Jul 28;2021:4861749. doi: 10.1155/2021/4861749

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Copyright © 2021 Yun Liu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Overexpression of lncRNA OIP5-AS1 could promote the apoptosis and restrain EC cells' tumorigenic potential. (a) Measurement of apoptotic cells with OIP5-AS1 overexpression by FACS assay and calculated percentage of apoptotic cells. ^∗∗∗P < 0.001 and ^∗P < 0.05. (b) Western blot analysis of cell death-related protein Bcl-2 and cleaved-caspase3, and the internal control is GAPDH. (c) Colony formation assay detected cell proliferation in OIP5-AS1-upregulated HEC-1-A cells and OIP5-AS1-downregulated KLE cells. (d, e) Transwell assay to test the invasion ability of HEC-1-A and KLE by altering the level of OIP5-AS1. ^∗∗∗P < 0.001. (f) Wound healing assay to identify the migration capacity of two EC cells after transfecting the OIP5-AS1 vector and Si-OIP5-AS1 for 48 hours. ^∗P < 0.05.