Table 3.
Clinicopathological features related to the integrated classification subtypes.
| Variable | N (%) | EBV+ (n = 6) | MSI∗ (n = 13) | E-cadherin aberrant (n = 28) | p53 aberrant (n = 31) | p53 normal (n = 19) | P value |
|---|---|---|---|---|---|---|---|
| Gender | 0.168 | ||||||
| -Male | 59 (60.8%) | 6 (100) | 7 (53.8) | 16 (57.1) | 19 (61.3) | 11 (57.9) | |
| -Female | 38 (39.2%) | 0 (0) | 6 (46.2) | 12 (42.9) | 12 (38.7) | 8 (42.1) | |
| Mean age at diagnosis (range) | 59 (28-85) | 61 (46-77) | 59 (36-85) | 56 (28-76) | 60 (39-80) | 65 (39-82) | 0.218 |
| Age at diagnosis | 0.581 | ||||||
| -≥50 years | 80 (82.5) | 5 (83.3) | 9 (69.2) | 22 (78.6) | 27 (87.1) | 17 (89.5) | |
| -<50 years | 17 (17.5) | 1 (16.7) | 4 (30.8) | 6 (21.4) | 4 (12.9) | 2 (10.5) | |
| History of gastrectomy | 0.055 | ||||||
| -Yes | 7 (7.2) | 1 (16.7) | 0 (0) | 3 (10.7) | 0 (0) | 3 (15.8) | |
| -No | 90 (92.8) | 5 (83.3) | 13 (100) | 25 (89.3) | 31 (100) | 16 (84.2) | |
| History of gastric ulcer | 0.023 | ||||||
| -Yes | 3 (3.1) | 2 (33.3) | 0 (0) | 0 (0) | 0 (0) | 1 (5.3) | |
| -No | 94 (96.9) | 4 (66.7) | 13 (100) | 28 (0) | 31 (100) | 18 (94.7) | |
| Tobacco smoking | 0.252 | ||||||
| -Yes | 25 (25.8) | 3 (50) | 1 (7.7) | 6 (21.4) | 10 (32.3) | 5 (26.3) | |
| -No | 72 (74.2) | 3 (50) | 12 (92.3) | 22 (78.6) | 21 (67.7) | 14 (73.7) | |
| Tumor location | 0.186 | ||||||
| -Cardia | 31 (31.9) | 2 (33.3) | 4 (30.8) | 11 (39.3) | 12 (38.7) | 2 (10.5) | |
| -Noncardia | 66 (68.1) | 4 (66.7) | 9 (69.2) | 17 (60.7) | 19 (61.3) | 17 (89.5) | |
| Tumor cells differentiation | 0.051 | ||||||
| -Well/moderate | 62 (63.9) | 2 (33.3) | 7 (53.8) | 15 (53.6) | 26 (83.9) | 12 (63.2) | |
| -Poor | 35 (36.1) | 4 (66.7) | 6 (46.2) | 13 (46.4) | 5 (16.1) | 7 (36.8) | |
| Lauren classification | 0.002 | ||||||
| -Intestinal | 65 (67.1) | 3 (50) | 11 (84.6) | 11 (39.3) | 26 (83.9) | 14 (73.7) | |
| -Diffuse/mixed | 32 (32.9) | 3 (50) | 2 (15.4) | 17 (60.7) | 5 (16.1) | 5 (26.3) | |
| HER2 immunostaining | 0.789 | ||||||
| -Positive | 9 (9.3) | 1 (16.7) | 1 (7.7) | 2 (7.1) | 2 (6.5) | 3 (15.8) | |
| -Negative | 88 (90.7) | 5 (83.3) | 12 (92.3) | 26 (92.9) | 29 (93.5) | 16 (84.2) | |
| PD-L1 immunostaining | n = 38 | n = 3 | n = 6 | n = 10 | n = 11 | n = 8 | 0.324 |
| -Positive | 6 (15.8) | 1 (33.3) | 3 (50) | 0 (0) | 1 (9.1) | 1 (12.5) | |
| -Negative | 32 (84.2) | 2 (66.7) | 3 (50) | 10 (100) | 10 (90.9) | 7 (87.5) |
EBV: Epstein-Barr virus; MSI: microsatellite instability; ∗previously reported [13].