Table 5.
Differentially expressed genes in exosomes and KEGG enrichment.
| Gene | log2 (Fold_change) | P value | KEGG pathway | |
|---|---|---|---|---|
| Up | ALG10 | 5.91 | 3.24E-04 | N-Glycan biosynthesis; metabolic pathways |
| UBE2G2 | 5.64 | 2.95E-05 | Ubiquitin-mediated proteolysis; protein processing in endoplasmic reticulum | |
| ZMAT3 | 3.49 | 1.30E-04 | p53 signaling pathway | |
| CCNT2 | 3.04 | 1.72E-05 | Transcriptional misregulation in cancer | |
| C1D | 2.28 | 5.08E-04 | RNA degradation | |
| ARHGAP5 | 2.20 | 1.67E-04 | Leukocyte transendothelial migration; focal adhesion | |
| TAOK1 | 1.92 | 3.38E-04 | MAPK signaling pathway | |
| GALNT1 | 1.92 | 6.46E-05 | Mucin type O-glycan biosynthesis; metabolic pathways | |
| CD2AP | 1.55 | 2.41E-04 | Bacterial invasion of epithelial cells | |
| HNRNPM | 1.40 | 3.13E-04 | Spliceosome | |
|
| ||||
| Down | CSF1 | -8.66 | 7.76E-07 | Ras signaling pathway; Rap1 signaling pathway; TNF signaling pathway; PI3K-Akt signaling pathway; cytokine-cytokine receptor interaction |
| DSG1 | -8.33 | 6.55E-06 | Staphylococcus aureus infection | |
| NTNG2 | -7.80 | 1.97E-04 | Cell adhesion molecules; axon guidance | |
| NR1H3 | -7.06 | 1.02E-04 | PPAR signaling pathway; insulin resistance; hepatitis C; nonalcoholic fatty liver disease | |
| CYP1A2 | -6.63 | 5.54E-04 | Linoleic acid metabolism; tryptophan metabolism; retinol metabolism; steroid hormone biosynthesis; drug metabolism- cytochrome P450; metabolic pathways; chemical carcinogenesis | |
| MECOM | -5.36 | 1.44E-04 | MAPK signaling pathway; chronic myeloid leukemia; pathways in cancer | |
| RELN | -4.79 | 1.39E-04 | ECM-receptor interaction; PI3K-Akt signaling pathway; focal adhesion | |
| PLA2G4B | -4.23 | 3.12E-04 | Linoleic acid metabolism; Glutamatergic synapse; Ras signaling pathway; Arachidonic acid metabolism; alpha-Linolenic acid metabolism; ether lipid metabolism; VEGF signaling pathway; fc epsilon RI signaling pathway; MAPK signaling pathway; GnRH signaling pathway; inflammatory mediator regulation of TRP channels; phospholipase D signaling pathway; oxytocin signaling pathway | |
| GRIN2A | -3.58 | 5.94E-04 | cAMP signaling pathway; glutamatergic synapse; Ras signaling pathway; calcium signaling pathway; Rap1 signaling pathway | |
| PRKDC | -3.03 | 1.28E-04 | Cell cycle; nonhomologous end-joining | |