Table 5.
Base mutation sites and amino acid substitution in ERG11 gene of C. albicans
| Strains | Resistance to FCA/ITR/VRC | Base mutation sits | Amino acid substitution |
|---|---|---|---|
| CA‐1 | VRC | T1431C | No |
| CA‐6 | FCA | C363T/T462C/C558T/T696C/C805T/A1587G | No |
| CA‐7 | FCA | T462C/T495A/C558T/T1143C/A1230G/C1257T/T1431C/A1587G/T1617C | D116E |
| CA‐9 | FCA/ITR/VRC | T462C/T495A/A530C/A1587G/T1617C | D116E/K128T |
| CA‐10 | VRC | T1431C | No |
| CA‐11 | ITR | T462C/T495A/A1167G/A1587G | D116E |
| CA‐14 | S | T462C/T495A/A1587G | D116E |
| CA‐15 | VRC | C363T/T462C/C558T/T696C/C805T/T1143C/A1173G/C1257T/T1350C/C1443T/T1449C/G1609A | V488I |
| CA‐18 | FCA/ITR/VRC | T462C/T495A/C515T/C1257T/A1587G | D116E/T123I |
| CA‐20 | S | C363T/C558T/C805T/A1167G/A1587G | No |
| CA‐23 | VRC | A1167G/C1443T/A1587G | No |
| CA‐26 | FCA/ITR/VRC | T462C/T495A/C558T/C1257T/T1350C/T1431C/A1587G/T1617C/G1693C | D116E/A516P |
| CA‐29 | ITR | T462C/T495A/A530C/C558T/C1257T | D116E/K128T |
| CA‐30 | VRC | T462C/T495A/A1230G/C1257T/T1350C/T1431C/A1587G/T1617C | D116E |
| CA‐31 | ITR | C363T/T462C/C558T/C805T/A1167G/A1587G | No |
| CA‐32 | FCA | T462C/T495A/A530C/A1587G | D116E/K128T |
| CA‐33 | ITR | T462C/T495A/A1587G | D116E |
| CA‐35 | ITR | C363T/T462C/C558T/T696C/C805T/T1143C/C1257T/T1350C/C1443T/T1449C/G1609A | V488I |
| CA‐37 | FCA/ITR/VRC | T462C/T495A/C558T/C805T/T1143C/A1173G/C1257T/T1350C/C1443T/T1449C | D116E |
| CA‐38 | VRC | T462C/T495A/A1587G | D116E |
| CA‐40 | FCA/ITR/VRC | T462C/T495A/A530C/A1587G | D116E/K128T |
| CA‐41 | FCA | T462C/T495A/A1167G/A1587G | D116E |
| CA‐42 | ITR | A1167G/A1587G | No |
| CA‐45 | FCA/ITR/VRC | C363T/T462C/A504G/C558T/T696C/C805T/A1587G | No |
| CA‐48 | FCA | A1167G/C1257T/A1587G | No |
| CA‐49 | ITR | A1587G | No |
| CA‐52 | FCA/ITR/VRC | C363T/T462C/C558T/C805T/T1143C/A1173G/T1350C/C1443T/T1449C | No |
| CA‐54 | FCA/ITR/VRC | C363T/T462C/C558T/T696C/C805T/A1173G/T1350C/T1449C/G1609A | V488I |
| CA‐56 | FCA/ITR/VRC | T462C/T495A/A504G/A530C/T541C/C558T | D116E/K128T/Y132H |
| CA‐59 | VRC | T462C/T495A/A1587G | D116E |
| CA‐60 | FCA | C363T/T462C/C558T/C805T/T1143C | No |
| CA‐61 | ITR | A1230G/T1431C | No |
| CA‐63 | FCA | A1587G | No |
| CA‐66 | ITR | T1431C | No |
| CA‐94 | FCA | C363T | No |
Abbreviations: A, alanine; D, aspartic acid; E, glutamic acid; FCA, fluconazole; FICI, fractional inhibitory concentration index; H, histidine; I, isoleucine; K, lysine; P, proline; RIT, ritonavir; S, sensitive to FCA, ITR and VRC; T, threonine; V, valine; Y, tyrosine.