PD ameliorated weight loss, colon length, DAI, and intestine damage in DSS‐induced mice. (A) The weight loss (the initiation weight of mice—the weight of DSS treated for 6 days' mice) of PD or DSS treated mice (the mice number is 14, n = 14). (B) Colon length of PD or DSS treated mice (n = 14). (C) H&E staining analysis the damage score of PD or DSS treatment mice, magnification is ×20 (n ≥ 4). (D) DAI of PD or DSS treatment mice (n = 14). (E) Immunohistochemistry analysis the expression of MPO l, which representative the amount of neutrophil, black arrow mark the protein, magnification is ×20 (n ≥ 4). DAI, disease activity index; DSS, dextran sodium sulfate; H&E, hematoxylin and eosin; PD, polydatin. *p < 0.05, **p < 0.01