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Assembly and activation of the AIM2 inflammasome. Sensing abnormal dsDNA in the cytoplasm triggers the assembly of the AIM2 inflammasome. The adapter protein ASC and the effector protein procaspase‐1 are recruited to participate in this activation process. AIM2, absent in melanoma 2; ASC, apoptosis‐associated speck‐like protein containing a CARD; dsDNA, double stranded DNA; GSDMD, gasdermin‐D; IL, interleukin
