Table 1.

Role of AIM2 in immune cells

Cell types	Role of AIM2	References
Macrophages	AIM2 inflammasome activation leads to antimicrobial host immune responses	3, 4, 5, 27, 28, 33
	AIM2 inflammasome over‐activation leads to abnormal functional maturation of macrophages thereby facilitating the progression of SLE
	AIM2 inflammasome activation leads to high levels of IL‐18 secretion from Kupffer cells thereby promoting hepatic NK cell activity and increasing NK cell‐dependent IFN‐γ
	Induction caspase 1‐mediated cleavage of cGAS thereby upregulating PD‐L1 and IDO, which inhibit antibody‐dependent cellular cytotoxicity and T cell‐mediated cytotoxicity to evade the adaptive response
DCs	AIM2 inflammasome activation leads to antimicrobial host immune responses	34, 35, 36, 37
	AIM2 inflammasome participates in the process of CD137L‐mediated monocyte to DC differentiation
	AIM2 inflammasome activation leads to high levels of IL‐1α production thereby promoting lung cancer cell proliferation
Neutrophils	Expression of key components of AIM2 inflammasome	38
T cells	Induction antigen‐specific antibody response thereby enhancing adaptive immunity of CD8+ T cells	39, 40, 41, 42, 43
	Upregulation of AIM2 in Treg restrain autoimmune diseases by reducing AKT–mTOR signaling and a T cell‐intrinsic role
B cells	Upregulation of AIM2 in gastric B cells inhibits CXCL16 production in the control of infiltration and retention of CD8+ T cells within chronic inflammatory tissues	44, 45
	Upregulation of AIM2 preferential in mature memory CD27+ B cells of adults
	Downregulation of AIM2 by FOXP1 in mature human B cells

Abbreviations: AIM2, absent in melanoma 2; DCs, dendritic cells; IFN‐γ, interferon γ; IL, interleukin; SLE, systemic lupus erythematosus.