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. 2021 May 6;9(3):827–839. doi: 10.1002/iid3.437

Figure 4.

Figure 4

PAQR3 aggravates ferroptosis in ALL. (A) The cell viability of CEM‐C1 and Jurkat cells was verified through CCK‐8 assay in the Vector + DMSO, PAQR3 + DMSO, Vector + RSL3, PAQR3 + RSL3, Vector + RSL3 + Fer‐1, and PAQR3 + RSL3 + Fer‐1 groups. (B–D) The levels of MDA, DCF and Fe in CEM‐C1 and Jurkat cells were tested through the appropriate kits in the Vector + DMSO, PAQR3 + DMSO, Vector + RSL3, PAQR3 + RSL3, Vector + RSL3 + Fer‐1, and PAQR3 + RSL3 + Fer‐1 groups. (E) The apoptosis rate of CEM‐C1 and Jurkat cells was measured through flow cytometry in the Vector + DMSO, PAQR3 + DMSO, Vector + RSL3, PAQR3 + RSL3, Vector + RSL3 + Fer‐1, and PAQR3 + RSL3 + Fer‐1 groups. Fer‐1: 1 μM; RSL3: 0.1 μM. *p < .05, **p < .01; # p < .05, ## p < .01; & p < .05, && p < .01. ALL, acute lymphoblastic leukemia; CCK‐8, Cell Counting Kit‐8; DMSO, dimethyl sulfoxide