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. 2021 Aug 2;8(4):ENEURO.0059-21.2021. doi: 10.1523/ENEURO.0059-21.2021

Figure 5.

Figure 5.

APs recorded and simulated from the same axon under different instrumental distortions predicted similar native spike shapes. A, Representative target APs (black) and their best-fit representations in the complex instrument+axon model with standard CPN settings (red, 7 pF), with slightly reduced CPN (purple, 6.5 pF) or with the highest attainable CPN level (blue, 7.386 pF). The parameters of the APs recorded with different CPN settings are shown in the Extended Data Figure 5-1. B, The best-fit gNamax and gKmax were similar from APs with different CPN levels (n = 30, 30, and 28 target APs). The voltage dependence and the kinetic profile of the optimal conductance sets are presented in the Extended Data Figure 5-2. C, The native AP waveforms retrieved from APs with different CPN levels were also similar. D, Peak, maximal dV/dt and half-width of the native APs predicted based on recordings with three different CPN settings. Columns show the averages of the native APs, while X denotes the averages of the experimentally measured parameters (n = 30, 30, and 28 APs) which were distorted by the instruments.