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. 2021 Aug 2;8(4):ENEURO.0059-21.2021. doi: 10.1523/ENEURO.0059-21.2021

Table 2.

Effect of axonal diameter and the Rseal on the model predictions

Standard
model		 Reduced
Rseal 		Reduced
diameter
(−180 nm)		 Increased
diameter
(+160 nm)		 Increased
diameter
(+30%)
Passive parameters Rm (kΩ/cm2) 60.01 72.92 38.88 62.97 66.83
Cm (μF/cm2) 0.65 0.62 0.99 0.62 0.58
Ri (Ω*cm) 147.3 141.54 56.78 208.08 205.03
Normalized error 2.96 3.05 3.18 2.95 2.93
Active conductances for
APs recorded witd
CPN = 6.5 pF		 gNa (mS/cm2) 159.02 ± 1.73 160.24 ± 2.1 229.79 ± 3.57 150.24 ± 1.86 146.63 ± 1.55
gK (mS/cm2) 5.83 ± 0.05 5.46 ± 0.04 12.74 ± 0.56 5.33 ± 0.04 5.29 ± 0.05
Normalized error 5.2 ± 0.16 5.09 ± 0.16 5.72 ± 0.19 5.22 ± 0.16 5.35 ± 0.17
Active conductances
for APs recorded
witd CPN = 7 pF		 gNa (mS/cm2) 151.7 ± 0.95 150.29 ± 1.06 232.6 ± 1.5 142.27 ± 0.97 137.95 ± 0.85
gK (mS/cm2) 5.41 ± 0.03 5.08 ± 0.03 9.23 ± 0.08 5.08 ± 0.03 4.85 ± 0.03
Normalized error 5.89 ± 0.17 5.92 ± 0.17 6.04 ± 0.19 6.36 ± 0.18 6.09 ± 0.17
Active conductances
for APs recorded witd
CPN = 7.386 pF		 gNa (mS/cm2) 160.03 ± 1.47 142.26 ± 1.17 249.13 ± 2.44 144.38 ± 1.23 138.84 ± 1.08
gK (mS/cm2) 6.32 ± 0.09 6.08 ± 0.44 11.24 ± 0.146 5.87 ± 0.07 5.71 ± 0.05
Normalized error 6.8 ± 0.28 8.22 ± 0.34 7.35 ± 0.3 8.1 ± 0.3 7.49 ± 0.26
n = 30 AP reconstitution
AP parameters
(reconstructed
measurement)		 dV/dtmax (V/s) 363.26 ± 0.93 369.87 ± 6.04 372.7 ± 0.96 354.99 ± 0.8 364.5 ± 0.78
Peak (mV) 9.01 ± 0.12 9.01 ± 0.49 9.24 ± 0.12 8.98 ± 0.12 8.93 ± 0.12
Threshold (mV) −45.28 ± 0.07 −45.29 ± 0.06 −45.69 ± 0.06 −45.17 ± 0.07 −45.36 ± 0.06
Half-width (ms) 0.52 ± 0.002 0.52 ± 0.004 0.52 ± 0.002 0.51 ± 0.002 0.52 ± 0.002
AP parameters
(local in the axon)		 dV/dtmax (V/s) 453.11 ± 2.54 453.82 ± 2.53 481.59 ± 3.06 450.44 ± 2.34 459.79 ± 2.34
Peak (mV) 21.96 ± 0.12 21.23 ± 0.12 22.34 ± 0.11 22.13 ± 0.12 22.08 ± 0.12
Threshold (mV) −35.88 ± 0.09 −35.92 ± 0.09 −36.97 ± 0.09 −36.01 ± 0.09 −36.12 ± 0.09
Half-width (ms) 0.48 ± 0.002 0.49 ± 0.002 0.49 ± 0.002 0.48 ± 0.002 0.48 ± 0.002
AP parameters
(native, I-step evoked)		 dV/dtmax (V/s) 1064.81 ± 5.1 1111.03 ± 5.76 914.95 ± 6.32 865.03 ± 4.65 854.73 ± 4.62
Peak (mV) 46.85 ± 0.09 47.34 ± 0.09 40.26 ± 0.15 40.06 ± 0.12 38.67 ± 0.14
Threshold (mV) −37.36 ± 0.09 −37.64 ± 0.09 −36.7 ± 0.09 −35.93 ± 0.09 −35.67 ± 0.09
Half-width (ms) 0.33 ± 0.002 0.33 ± 0.002 0.34 ± 0.002 0.33 ± 0.002 0.34 ± 0.002
AP parameters
(native, propagating)		 dV/dtmax (V/s) 1605.96 ± 9.75 1671.34 ± 10.82 1549.38 ± 12.2 1609.7 ± 10.18 1630.3 ± 9.82
Peak (mV) 64.21 ± 0.07 64.71 ± 0.07 63.29 ± 0.11 64.16 ± 0.08 64.24 ± 0.07
AP width at −10 mV (ms) 0.36 ± 0.002 0.35 ± 0.002 0.36 ± 0.002 0.36 ± 0.002 0.36 ± 0.002
Propagation velocity (ms) 0.45 ± 0.001 0.48 ± 0.002 0.43 ± 0.002 0.46 ± 0.002 0.46 ± 0.001