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. 2021 Jun 25;40(31):4955–4966. doi: 10.1038/s41388-021-01904-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A–C ERMS growth monitored by µCT measurements before and 7 weeks after tamoxifen-mediated induction of the oncRAS mutations in A Ptch^+/−HRas^fl/+Myf5^CreER/wt B Ptch^+/−KRas^fl/+Myf5^CreER/wt or C Ptch^+/−NRas^fl/+Myf5^CreER/wt mice. At least 12 animals were analyzed per cohort. Left: mean relative tumor volumes before and 7 weeks after injection (ln: logarithmic scale). Middle: relative growth of individual tumors (logarithmic scale). Right: percentage of Ki67⁺ nuclei in the tumors. Solvent-treated mice served as controls. All ERMS of the same mouse were analyzed as individual tumors. Dots: results for individual tumors. Statistical analyses of mean tumor growth or the individual tumor growth and the percentage of Ki67+ nuclei were done by Student’s t-tests or non-parametric t-tests (Mann–Whitney), respectively.