Table 1.
Mice analyzed for the impact of oncRAS on ERMS precursor lesions.
| Treatment | Number of animals | Median overall survival (range) |
Healthy // early death | Mice with ERMS (palpable and non-palpable) |
Mice with palpable ERMS | Mice with ≥ 2 ERMS (palpable and non-palpable) |
Median latency time of palpable ERMS | Further findings (number of animals) |
|---|---|---|---|---|---|---|---|---|
| Ptch+/−HRasfl/+Myf5CreER/wt | ||||||||
| Control | 30 |
200 days (65–211) |
18 // 12 |
17 (57 %) |
14 (47 %) |
6 (20 %) |
97 days |
Cysts/Cavernous angioma(4), Medullo-blastoma(3), Papilloma (1) |
| Tamoxifen | 29 |
200 days (78–204) |
19 // 9 |
22 (76 %) |
19 (66 %) |
6 (21 %) |
85 days | Cysts/Cavernous angioma(4), Medullo-blastoma(1), Papilloma (1) |
| Ptch+/−KRasfl/+Myf5CreER/wt | ||||||||
| Control | 21 |
200 days (83–209) |
14 // 7 |
9 (43 %) |
8 (38 %) |
4 (19 %) |
103 days | Cysts/Cavernous angioma (2), Medullo-blastoma (3) |
| Tamoxifen | 24 |
122 days (69–204) |
6 // 18 |
20 (83 %) |
17 (58 %) |
12 (50 %) |
85 days | Cysts/Cavernous angioma (4), Medullo-blastoma (0) |
| Ptch+/−NRasfl/+Myf5CreER/wt | ||||||||
| Control | 26 |
200 days (131–212) |
20 // 6 |
16 (62 %) |
14 (54 %) |
10 (38 %) |
70 days | Cysts/Cavernous angioma (4), Medullo-blastoma (2) |
| Tamoxifen | 26 |
200 days (76–206) |
21 // 5 |
19 (73 %) |
17 (65 %) |
8 (31 %) |
94 days | Cysts/Cavernous angioma (6), Medullo-blastoma (1) |
| Ptch+/− | ||||||||
| Control | 24 |
200 days (60–208) |
20 // 4 |
12 (50 %) |
12 50 %) |
3 (13 %) |
80 days | Cysts/Cavernous angioma (5), Medullo-blastoma (0) |
| Tamoxifen | 26 | 200 days (90–209) | 19 // 7 |
12 (46 %) |
12 (46 %) |
4 (15 %) |
105 days | Cysts/Cavernous angioma (4), Medullo-blastoma (2) |
The ERMS-like tumors develop mostly at the extremities. They may also develop in muscles of the belly and the back. Intraperitoneal localized tumors were discovered by manual palpation or upon autopsy, as were very small tumors. There were no significant differences in tumor locations between the genotypes. Medulloblastomas harm the animals. These mice were immediately sacrificed and checked for non-palpable ERMS. The coloring of the table is very confusing.