Table 1.

Correlations between Rb and 4 pharmacokinetics (PK) parameters

PK parameter	Transformation	R	p-value
Vd	log	0.47	< 0.0001
fp	log	0.42	< 0.0001
fp	–	0.35	< 0.0001
CL	log	0.30	< 0.0001
CL	–	0.25	< 0.0001
Vd	–	0.25	< 0.0001
MRT	log	0.16	0.008
MRT	–	0.03	0.5939

(Logarithmically [log] transformed or not [-]) (n  =  270)

Clearance (CL), volume of distribution (Vd), mean resistance time (MRT), free fraction plasma protein binding (fp)

p-values were calculated based on analysis of variance