Table 2.

Risk of CV conditions in patients with chronic hypoparathyroidism compared with those without chronic hypoparathyroidism

Outcomea	HR	95% CI	P value
AF
Unadjusted	2.80	2.46–3.18	< 0.001
Adjustedb	1.72	1.51–1.97	< 0.001
Cerebrovascular disease
Unadjusted	2.43	2.22–2.66	< 0.001
Adjustedb	1.48	1.34–1.62	< 0.001
CAD
Unadjusted	2.21	2.01–2.43	< 0.001
Adjustedb	1.39	1.26–1.54	< 0.001
MI
Unadjusted	1.86	1.61–2.15	< 0.001
Adjustedb	1.18	1.01–1.38	0.036
HF
Unadjusted	3.03	2.72–3.37	< 0.001
Adjustedb	1.64	1.46–1.84	< 0.001
PVD
Unadjusted	2.77	2.54–3.03	< 0.001
Adjustedb	1.66	1.51–1.81	< 0.001
Stroke
Unadjusted	2.40	2.18–2.66	< 0.001
Adjustedb	1.45	1.31–1.62	< 0.001
Tachyarrhythmia
Unadjusted	2.52	2.01–3.15	< 0.001
Adjustedb	1.68	1.32–2.14	< 0.001
Combined CV endpointc
Unadjusted	2.60	2.43–2.77	< 0.001
Adjustedb	1.63	1.52–1.75	< 0.001

AF atrial fibrillation, CAD coronary artery disease, CI confidence interval, CKD chronic kidney disease, CV cardiovascular, HF heart failure, HR hazard ratio, MI myocardial infarction, PVD peripheral vascular disease

^aPatients without hypoparathyroidism served as the reference group for all analyses

^bMultivariable Cox models adjusted for demographic (age, sex, race, region, and index year) and clinical (other comorbid CV conditions, CKD, hyperlipidemia, hypertension, diabetes, and use of CV medications) characteristics at baseline

^cIncluding cerebrovascular disease, CAD, HF, and PVD