Fig. 1.

Time to a first bone metastasis, b bone metastasis as site of first recurrence with non-bone site of first recurrence as a competing risk, c first symptomatic bone metastasis with asymptomatic bone metastasis as a competing risk, d first on-study fracture (before bone metastasis), and e first on-study SRE (following bone metastasis). CI confidence interval, HR hazard ratio, SRE skeletal-related event. *Based on subdistribution hazards (Gray [10] and Zhou et al. [11]) stratified by the randomization stratification factors