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. 2021 Jul 19;38(8):4520–4540. doi: 10.1007/s12325-021-01823-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — mCRPC treatment sequences: time on and time off treatment. 1L first line, 2L second line, 3L third line; Chemo chemotherapy, Combo combination therapy, LOT line of therapy, mCRPC metastatic castration-resistant prostate cancer, NHA next-generation hormonal agent, Sip-T sipuleucel-t. *For Sip-T only the start date is available in the data, and thus we cannot distinguish between time on and off treatment for this agent. 1. Only the top 10 sequences are shown (of a total of 25 observed 1L → 2L sequences and 97 observed 1L → 2L → 3L sequences; of note, there are a total of 25 possible sequences for 1L → 2L and a total of 125 possible 1L → 2L → 3L sequences by combining 5 treatment classes across 2 and 3 LOTs, respectively)