Table 1.

National total and weighted mean economic burden per patient and caregiver by category

Scenario	Driving-related costs	Indirect costs	Flights	Lodging and meals		Total costs
Total costs
(A) Academic hospitals only
Patients who required flights and/or lodging/meals, %			1.8	37.3
Costs
Patient	$548,671	$1,495,674	$31,324	$10,207,995		$12,283,663
Caregiver	$1,591,145	$2,959,243	$31,324	$4,257,495		$8,839,207
Total	$2,139,815	$4,454,917	$62,648	$14,465,490		$21,122,871
	Ref.	Ref.	Ref.	Ref.		Ref.
(B) Academic and community multispecialty hospitals only
Patients who required flights and/or lodging/meals, %			1.4	30.4***
Costs
Patient	$482,954	$1,117,184	$22,999	$8,333,748		$9,956,884
Caregiver	$1,400,565	$2,216,665	$22,999	$3,502,369		$7,142,598
Total	$1,883,519	$3,333,849	$45,997	$11,836,117		$17,099,482
Difference from scenario A	($256,297)	($1,121,068)	($16,651)	($2,629,373)		($4,023,389)
(C) Any specialized treatment facility
Patients who required flights and/or lodging/meals, %			0.5***	26.2***
Costs
Patient	$466,087	$1,107,887	$8934	$6,778,134		$8,361,043
Caregiver	$1,351,653	$1,998,276	$8934	$2,941,107		$6,299,969
Total	$1,817,740	$3,106,163	$17,868	$9,719,241		$14,661,012
Difference from scenario A	($322,075)	($1,348,754)	($44,780)	($4,746,249)		($6,461,858)
Weighted mean costs per patient
(A) Academic hospitals only
Patient	$139	$380	$8	$2594		$3121
Caregiver	$404	$752	$8	$1082		$2246
Total	$544	$1132	$16	$3676		$5368
	Ref.	Ref.	Ref.	Ref.		Ref.
(B) Academic and community multispecialty hospitals only
Patient	$123	$283	$6	$2114		$2526
Caregiver	$355	$562	$180	$889		$1986
Total	$478	$846	$185	$3003		$4512**
Difference from scenario A	($66)	($286)	($169)	($673)		($856)
(C) Any specialized treatment facility
Patient	$119	$282	$2	$1728		$2132
Caregiver	$345	$509	$2	$750		$1606
Total	$463	$792	$5	$2478		$3738***
Difference from scenario A	($80)	($340)	($11)	($1198)		($1630)

Values may not sum due to rounding

Ref. reference

*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001