. 2021 Aug 5;12(8):770. doi: 10.1038/s41419-021-04045-4

Table 1.

Correlation between the proliferation, sXBP1 and ATF6 expression and peIF2α levels in CDG and CDDG cell lines treated with candidate and non-active control compounds.

Compounds	NGLY1⁻^/−				PMM2^F119L/−				DPAGT1^+/−
Compounds	Proliferation	sXBP1	peIF2α	ATF6	Proliferation	sXBP1	peIF2α^a	ATF6^a	Proliferation	sXBP1	peIF2α	ATF6
Candidates Group I
1	**	ns			ns	ns			ns	ns
2	****	ns			ns	ns			ns	ns
3	ns	****			***	ns			****	*
4	ns	****			ns	ns			ns	**
5	ns	*			*	ns			ns	ns
6	****	****	****	***	****	**	ns	ns	***	**	****	****
9	***	****	****	*	***	**	ns	ns	****	***	****	****
Candidates Group II
14	ns	****			ns	ns			ns	***
15	****	****	****	**	****	**	ns	ns	****	****	****	****
16	***	ns			ns	ns			ns	ns
18	****	ns			ns	ns			ns	ns
25	ns	****			****	**			****	****
26	ns	****	****	**	****	***	ns	ns	****	****	****	***
Non-active controls
28	ns	ns	ns	ns	ns	ns	ns	ns	ns	ns	****	ns
29	ns	ns			ns	ns			ns	ns
30	ns	ns			ns	ns			ns	ns
31	ns	ns			ns	ns			ns	ns
32	ns	ns			ns	ns			ns	ns
33	ns	ns			ns	ns			ns	ns
34	ns	ns			ns	ns			ns	ns
35	ns	ns			ns	ns			ns	ns
36	ns	ns			ns	ns			ns	ns
37	ns	ns			ns	ns			ns	ns
38	ns	ns			ns	ns			ns	ns

^aNo phenotype for these ER stress markers.

*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.