Table 1.

Changes in the serum concentrations of thyroid hormones and six major protein fractions across normal pregnancy.

Parameter	Mean ± SD, (CV)*, median, range			p ANOVA
	Trimester of pregnancy
	First (n = 55)	Second (n = 42)	Third (n = 39)
TSH [µIU/dl]	211 ± 205 (97%) 173 (10–1100)	205 ± 157 (76%) 182 (7–1056)	214 ± 88 (48%) 204 (33–415)	p = 0. 138
fT4 [ng/dl]	1.19 ± 0.17 (14%) 1.21 (0.71–1.50)	1.02 ± 0.12 (13%) 0.99 (0.77–1.27)	0.90 ± 0.15 (17%) 0.88 (0.64–1.41)	I vs II p = 0.000 I vs III = 0.000 II vs III p = 0.008
fT3 [ng/dl]	0.31 ± 0.04 (11%) 0.31 (0.22–0.39)	0.28 ± 0.04 (16%) 0.28 (0.21 –0. 44)	0.27 ± 0.03 (12%) 0.27 (0.22–0.35)	I vs II p = 0.002 II vs III p = 0.000
fT3/fT4	0.26 ± 0.04 (16%) 0.26 (0.17–0.37)	0.28 ± 0.05 (18%) 0.27 (0.19–0.40)	0.31 ± 0.06 (19.81%) 0.32 (0.17–0.43)	I vs III p = 0.000 II vs III p = 0.039
Albumina [g/L]	36.1 ± 3.4 (9%) 36.0 (27.5–42.3)	31.2 ± 2.7 (9%) 31.0 (25.7–39.6)	29.6 ± 2,4 (8%) 29.5 (24.6–35.4)	I vs II p = 0.000 I vs III p = 0.000
Alpha-1-globulin [g/L]	2.3 ± 0.5 (20%) 2.3 (0.5–3.5)	2.6 ± 0.4 (14%) 2.7 (1.6–3.3)	2.7 ± 0.4 (13%) 2.7 (2.0–3.4)	I vs II p = 0.001 I vs III p = 0.000
Alpha-2-globulin [g/L]	9.9 ± 1.3 (13%) 9.7 (7.4–13.3)	10.5 ± 1.2 (11%) 10.6 (7.7–12.7)	10.4 ± 1.3 (12%) 10.4 (7.0–12.4)	p = 0.056
Beta-1-globulin [g/L]	6.6 ± 1.2 (18%) 6.5 (4.8–11.3)	7.0 ± 1.0 (14%) 6.8 (5.1–9.5)	7.4 ± 1.1 (14%) 7.6 (4.5–9.7)	I vs III p = 0.000
Beta-2-globulin [g/L]	4.8 ± 0.9 (18%) 4.8 (3.2–7.2)	4.5 ± 1.0 (21%) 4.4 (2.8–6.6)	4.4 ± 0.8 (18%) 4.4 (2.1–6.1)	p = 0.141
Gamma-globulin [g/L]	10.6 ± 2.4 (22%) 10.3 (5.9–18.9)	8.2 ± 1.8 (22%) 7.5 (4.5–12.4)	7.0 ± 2.1 (30%) 6.6 (3.2–11.7)	I vs II p = 0.000 I vs III p = 0.00