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. 2021 Aug 5;6:97. doi: 10.1038/s41541-021-00356-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Adenovirus is a dsDNA, non-enveloped virus mainly composed by the structural protein, hexon, and other components associated with its interaction with the host cells (penton base and knobbed fiber). b The early stage of the infection cycle is marked by the knob domain of the viral fiber interaction with the Coxsackie and Adenovirus Receptor (CAR), followed by the penton-base with αvβ integrins present in the cell surface. CAR is the main receptor for the adenovirus serotype 5, however other serotypes utilize different receptors for cell entry.