Skip to main content
. 2021 Aug 5;11:15950. doi: 10.1038/s41598-021-95321-y

Table 2.

Summary statistics on novel-HC genes.

Paper AUROC P20R (%) P43R (%)
Princeton 0.67 (0.60, 0.74) 0.88 (0.56, 1.00) 0.85 (0.47, 1.16)
FRN 0.73 (0.67, 0.79) 1.28 (0.69, 4.61) 0.87 (0.55, 1.33)
DAMAGES 0.80 (0.75, 0.85) 1.25 (0.87, 1.79) 1.40 (0.76, 1.90)
RF_Lin 0.77 (0.71, 0.83) 2.12 (0.96, 3.94) 1.49 (0.84, 1.87)
PANDA 0.72 (0.66, 0.79) 1.08 (0.44, 3.69) 0.68 (0.43, 0.96)
forecASD 0.89 (0.84, 0.94) 7.13 (4.63, 11.21) 5.56 (3.24, 9.38)
DAWN 0.58 (0.53, 0.63) 0.69 (0.37, 1.37) 0.53 (0.35, 0.72)a
ExAC_pLI 0.77 (0.72, 0.83) 1.14 (0.69, 1.92) 1.11 (0.78, 1.46)
gnomAD_pLI 0.75 (0.7, 0.81) 1.05 (0.70, 2.08) 1.15 (0.72, 1.39)
oe_LoF 0.79 (0.74, 0.84) 0.96 (0.64, 1.45) 1.10 (0.81, 1.37)
DeRubeis 0.72 (0.65, 0.79) 4.73 (2.08, 5.60) 2.37 (1.44, 3.77)
Sanders 0.76 (0.69, 0.84) 6.20 (3.49, 10.54) 2.80 (1.68, 6.33)
iHart 0.78 (0.71, 0.85) 42.35 (5.00, 58.33) 4.07 (1.69, 7.61)
Satterstrom 0.85 (0.79, 0.91) 50.00 (37.57, 75.79) 54.13 (24.41, 69.91)
Iossifov 0.76 (0.70, 0.82) 1.82 (1.24, 3.65) 1.83 (1.10, 2.68)

AUROC area under the receiver operator characteristic curve, P20R precision at 20% recall, P43R precision at 43% recall. Values in parentheses are the upper and lower 95% confidence interval bounds. aFor P43R indicates a tie at recall of 20/43% of gene set.