Table 3.
Summary statistics on SFARI-HC genes.
| Study | AUROC | P20R (%) | P43R (%) |
|---|---|---|---|
| Princeton | 0.81 (0.78, 0.84) | 6.14 (4.79, 7.58) | 4.36 (3.49, 6.02) |
| FRN | 0.88 (0.86, 0.90) | 8.00 (5.33, 12.06)a | 5.79 (4.53, 6.37) |
| DAMAGES | 0.87 (0.85, 0.90) | 7.36 (5.70, 8.90) | 7.13 (5.78, 8.78) |
| RF_Lin | 0.50 (0.44, 0.55) | 5.59 (3.49, 7.08) | 2.58 (0.53, 3.82) |
| PANDA | 0.87 (0.84, 0.89) | 7.67 (5.76, 11.99) | 5.78 (4.79, 6.80) |
| forecASD | 0.94 (0.92, 0.95) | 53.56 (38.23, 77.32) | 31.80 (23.85, 40.22) |
| DAWN | 0.62 (0.59, 0.65) | 3.00 (2.07, 7.62) | 1.70 (1.39, 2.02)a |
| ExAC_pLI | 0.88 (0.85, 0.91) | 12.06 (9.68, 14.08)a | 9.57 (8.31, 12.07)a |
| gnomAD_pLI | 0.88 (0.85, 0.91) | 11.42 (9.59, 12.96)a | 11.42 (9.29, 12.96)a |
| oe_LoF | 0.91 (0.89, 0.93) | 23.02 (13.80, 32.05) | 16.30 (12.29, 18.80)a |
| DeRubeis | 0.68 (0.63, 0.72) | 29.00 (11.89, 77.38) | 4.42 (1.68, 6.34) |
| Sanders | 0.73 (0.68, 0.77) | 85.29 (53.74, 95.00) | 12.45 (6.68, 20.99) |
| iHart | 0.73 (0.68, 0.77) | 74.36 (41.06, 97.22) | 14.28 (5.68, 28.05) |
| Satterstrom | 0.75 (0.70, 0.80) | 85.29 (65.48, 100.00) | 31.51 (16.37, 55.71) |
| Iossifov | 0.88 (0.86, 0.91) | 56.85 (43.99, 68.00)a | 31.00 (18.04, 44.85) |
Headings are per Table 2, and ameans a tie at recall of 20/43% of gene set.