Table 2.

Demographic and clinical characteristics of all adults (≥ 15 years) routinely treated for drug-susceptible TB in the South African reporting cohort, stratified by HIV status, aggregated for 2009–2016.

		HIV unknown		HIV-positive		HIV-negative		Total
		n	col %	n	col %	n	col %	n	col %
Total		395,486	100	1,443,557	100	712,015	100	2,551,058	100
Age category	15–24 years	59,020	14.9	126,747	8.8	157,973	22.2	343,740	13.5
	25–34 years	116,147	29.4	517,793	35.9	157,445	22.1	791,385	31.0
	35–44 years	99,473	25.2	480,515	33.3	120,213	16.9	700,201	27.4
	45–54 years	64,703	16.4	229,060	15.9	121,999	17.1	415,762	16.3
	55–64 years	33,439	8.5	73,147	5.1	87,547	12.3	194,133	7.6
	65 + years	22,704	5.7	16,295	1.1	66,838	9.4	105,837	4.1
Sex	Female	162,900	41.2	703,339	48.7	257,618	36.2	1,123,857	44.1
	Male	232,586	58.8	740,218	51.3	454,397	63.8	1,427,201	55.9
Previous TB disease	New	334,507	84.6	1,240,553	85.9	613,707	86.2	2,188,767	85.8
	Retreatment	60,979	15.4	203,004	14.1	98,308	13.8	362,291	14.2
Site of disease	EPTB	50,802	12.8	211,941	14.7	60,916	8.6	323,659	12.7
	PTB	344,684	87.2	1,231,616	85.3	651,099	91.4	2,227,399	87.3
Disseminated TBa	Not disseminated	350,036	97.0	1,283,236	95.7	656,757	98.6	2,290,029	96.7
	Disseminated	10,645	3.0	57,059	4.3	9495	1.4	77,199	3.3
Outcome 1b	Cured/completed	266,336	67.3	1,065,118	73.8	566,009	79.5	1,897,463	74.4
	Died	42,478	10.7	138,992	9.6	38,577	5.4	220,047	8.6
	Drug resistance	2310	0.6	9297	0.6	3881	0.5	15,488	0.6
	Failed	1426	0.4	4117	0.3	3403	0.5	8946	0.4
	Loss to follow up	57,240	14.5	157,657	10.9	75,641	10.6	290,538	11.4
	Transferred out	25,696	6.5	68,376	4.7	24,504	3.4	118,576	4.6
Outcome 2c	Favourable	266,336	67.3	1,065,118	73.8	566,009	79.5	1,897,463	74.4
	Unfavourable	129,150	32.7	378,439	26.2	146,006	20.5	653,595	25.6
Outcome 3d	Alive	270,072	86.4	1,078,532	88.6	573,293	93.7	1,921 897	89.7
	Dead	42,478	13.6	138,992	11.4	38,577	6.3	220,047	10.3
Year of TB treatment	2009	161,905	40.9	140,465	9.7	59,007	8.3	361,377	14.2
	2010	93,587	23.7	188,840	13.1	78,089	11	360,516	14.1
	2011	51,202	12.9	209,485	14.5	93,095	13.1	353,782	13.9
	2012	33,845	8.6	196,722	13.6	92,669	13	323,236	12.7
	2013	22,869	5.8	188,816	13.1	98,050	13.8	309,735	12.1
	2014	14,563	3.7	192,718	13.4	103,816	14.6	311,097	12.2
	2015	9413	2.4	173,058	12	98,118	13.8	280,589	11.0
	2016	8102	2	153,453	10.6	89,171	12.5	250,726	9.8

ETR.Net: electronic tuberculosis register; ICD10: International classification of disease 10; TB: tuberculosis; EPTB: extrapulmonary TB.

^aDisseminated TB was defined using the ICD10 coding, with miliary TB and neurological TB classified as disseminated TB and all other ICD10 codes as not disseminated. Missing ICD10 codes n = 183,830.

^bOutcome 1, as classified in ETR.Net, combining cure and complete for success; and all patients without outcomes as lost to follow up.

^cOutcome 2, a binary outcome with success as the only favourable outcome and all other outcomes considered unfavourable.

^dOutcome 3, patients in whom a final vitality status is unknown (lost to follow up, moved or not evaluated) n = 409,114 were excluded.