Table 4.
Comparison of morphological features between low and high Aβ cases.
| Low Aβ | High Aβ | P value | Low Aβ | High Aβ | P value | ||||
|---|---|---|---|---|---|---|---|---|---|
| Cell body volume (μm3) | Ctrl | 295.5 (221.8–421.5) | 237.0 (182.8–375.3) | 0.054 | Average primary process straightness (μm) | Ctrl | 0.760 (0.689–0.807) | 0.754 (0.708–0.798) | 0.879 |
| AD | 318.0 (232.0–431.0) | 302.0 (186.0–438.0) | 0.274 | AD | 0.766 (0.704–0.817) | 0.754 (0.701–0.810) | 0.525 | ||
| iAD | 263.0 (192.0–384.0) | 298.5 (184.0–478.0) | 0.218 | iAD | 0.772 (0.720–0.811) | 0.758 (0.716–0.806) | 0.445 | ||
| Cell body sphericity | Ctrl | 0.661 (0.580–0.716) | 0.650 (0.585–0.701) | 0.904 | Number of primary processes | Ctrl | 6.0 (4.8–8.0) | 6.0 (4.0–8.0) | 0.456 |
| AD | 0.621 (0.561–0.690) | 0.676 (0.620–0.752) | 0.272 | AD | 7.0 (4.0–9.0) | 5.0 (3.0–8.0) | 0.008 (0.71) | ||
| iAD | 0.641 (0.583–0.702) | 0.651 (0.579–0.721) | 0.721 | iAD | 7.0 (5.0–9.0) | 5.0 (4.0–8.0) | 0.003 (0.71) | ||
| Total secondary process length (μm) | Ctrl | 190.6 (86.2–322.5) | 105.9 (48.0–179.5) | 0.011 (0.56) | Total number of junctions | Ctrl | 26.0 (15.3–47.8) | 20.0 (10.3–32.8) | 0.019 (0.77) |
| AD | 130.7 (57.9–223.6) | 69.2 (23.1–139.5) | 0.001 (0.53) | AD | 24.0 (14.0–38.0) | 14.0 (6.0–25.0) | < 0.001 (0.58) | ||
| iAD | 135.7 (72.0–237.9) | 106.2 (41.9–205.4) | 0.048 (0.78) | iAD | 25.0 (14.0–39.0) | 18.5 (9.0–34.0) | 0.017 (0.74) | ||
| Average primary process length (μm) | Ctrl | 25.9 (15.6–30.2) | 18.9 (12.9–26.0) | 0.033 (0.73) | Number of junctions per primary process | Ctrl | 5.4 (2.0–7.3) | 3.3 (2.0–5.3) | 0.052 |
| AD | 17.2 (12.7–25.8) | 19.4 (10.6–24.1) | 0.779 | AD | 3.8 (2.0–6.2) | 2.3 (1.6–4.8) | 0.017 (0.61) | ||
| iAD | 18.6 (15.4–24.4) | 20.3 (14.8–27.0) | 0.519 | iAD | 3.8 (2.2–5.7) | 3.4 (1.9–5.6) | 0.056 | ||
| Total primary process length (μm) | Ctrl | 146.0 (81.5–196.6) | 118.6 (71.8–162.6) | 0.121 | Total process length (μm) | Ctrl | 339.9 (132.9–475.8) | 187.8 (102.0–324.9) | 0.015 (0.55) |
| AD | 129.6 (78.7–169.9) | 98.1 (51.0–130.7) | 0.005 (0.76) | AD | 219.1 (111.1–380.3) | 156.3 (70.5–258.6) | 0.003 (0.71) | ||
| iAD | 132.5 (98.0–169.2) | 123.7 (67.0–170.1) | 0.185 | iAD | 259.6 (144.9–402.5) | 216.8 (103.1–333.0) | 0.031 (0.84) | ||
Values are median with IQR.
P value by the independent samples Mann–Whitney U test (low Aβ vs high Aβ within each group).
Significant P values in bold with fold change (high Aβ with respect to low Aβ) between brackets.
Ctrl Control group.