Table 2.
MDD (N = 34) | HV (N = 32) | |||
---|---|---|---|---|
Female (n = 22) | Male (n = 12) | Female (n = 13) | Male (n = 19) | |
Age | 38.4 ± 11.0 | 35.0 ± 10.4 | 30.7 ± 5.1 | 36.9 ± 9.7 |
MADRS total | 30.1 ± 3.4 | 31.9 ± 3.4 | n.a. | n.a. |
Duration of current MDE | 10.9 ± 14.5 | 6.7 ± 10.6 | n.a. | n.a. |
Age of onset: 1st episode | 18.3 ± 8.2 | 17.7 ± 7.8 | n.a. | n.a. |
Glx/NAA | 1.19 ± 0.3 | 1.51 ± 0.4* | 1.09 ± 0.3 | 1.05 ± 0.2 |
Glu/NAA | 0.82 ± 0.2 | 1.08 ± 0.4* | 0.79 ± 0.3 | 0.83 ± 0.2 |
GABA/NAAa | 0.070 ± 0.01 | 0.075 ± 0.02 | 0.09 ± 0.03 | 0.09 ± 0.01 |
MDD major depressive disorder, HV healthy volunteer, MDE major depressive episode, MADRS Montgomery–Åsberg Depression Rating Scale.
aGABA/NAA subsample included 12 HV (6 female and 6 male).
*P < 0.05 compared to female MDD and HV.