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. 2021 Aug 5;11:419. doi: 10.1038/s41398-021-01541-1

Table 2.

Sex breakdown.

MDD (N = 34) HV (N = 32)
Female (n = 22) Male (n = 12) Female (n = 13) Male (n = 19)
Age 38.4 ± 11.0 35.0 ± 10.4 30.7 ± 5.1 36.9 ± 9.7
MADRS total 30.1 ± 3.4 31.9 ± 3.4 n.a. n.a.
Duration of current MDE 10.9 ± 14.5 6.7 ± 10.6 n.a. n.a.
Age of onset: 1st episode 18.3 ± 8.2 17.7 ± 7.8 n.a. n.a.
Glx/NAA 1.19 ± 0.3 1.51 ± 0.4* 1.09 ± 0.3 1.05 ± 0.2
Glu/NAA 0.82 ± 0.2 1.08 ± 0.4* 0.79 ± 0.3 0.83 ± 0.2
GABA/NAAa 0.070 ± 0.01 0.075 ± 0.02 0.09 ± 0.03 0.09 ± 0.01

MDD major depressive disorder, HV healthy volunteer, MDE major depressive episode, MADRS Montgomery–Åsberg Depression Rating Scale.

aGABA/NAA subsample included 12 HV (6 female and 6 male).

*P < 0.05 compared to female MDD and HV.