Table 1.
Baseline demographic and clinical characteristics of patients enrolled in the study.
| Parameter | No vaccination (n = 147) | PPV23 (n = 32) | PCV13 (n = 123) | p value (Kruskal–Wallis test) |
|---|---|---|---|---|
| Demography and anamnesis | ||||
| Age (years) | 63 (60:66) | 60 (55:64.25) | 61 (57:66) | 0.133 |
| Aged > 65 years | 56 [38.1%] | 8 [25%] | 36 [29.27%] | 0.181 |
| Age of COPD onset | 6 (4:7) | 6 (4:6.25) | 5 (2:8) | 0.103 |
| BMI (at baseline) | 21 (19:23) | 21 (19:23.25) | 21 (19:23) | 0.387 |
| COPD characteristics | ||||
| CAT (at baseline) | 25 (21.5:30) | 24 (21.8:30.3) | 25 (21:30.5) | 0.924 |
| MMRC | ||||
| Grade 2 | 19 [12.93%] | 6 [18.75%] | 12 [9.76%] | 0.219 |
| Grade 3 | 76 [51.7%] | 18 [56.25%] | 56 [45.53%] | |
| Grade 4 | 52 [35.37%] | 8 [25%] | 55 [44.72%] | |
| BODE index | 5 (4:6) | 5 (4:5.25) | 5 (4:6) | 0.193 |
| 6MWT (at baseline) | 370 (318:456) | 390 (313:497) | 370 (340:425) | 0.453 |
| SGRQ | 39 (35:47) | 37.5 (33:47) | 38 (35:46) | 0.477 |
| Exacerbations over the year preceding vaccination | ||||
| None | 24 [16.33%] | 7 [21.88%] | 22 [17.89%] | 0.619 |
| One exacerbation | 122 [82.99%] | 25 [78.12%] | 98 [79.67%] | |
| Two exacerbations | 1 [0.68%] | 0 [0%] | 3 [2.44%] | |
| Hospitalizations (for the exacerbation or routine) over the year preceding vaccination | ||||
| None | 13 [8.84%] | 4 [12.5%] | 10 [8.13%] | 0.625 |
| One hospitalization | 133 [90.48%] | 28 [87.5%] | 110 [89.43%] | |
| Two hospitalizations | 1 [0.68%] | 0 [0%] | 3 [2.44%] | |
| Pneumonia episodes | ||||
| Pneumonia episodes over the year preceding vaccination, total | ||||
| None | 120 [81.63%] | 24 [75%] | 104 [84.55%] | 0.492 |
| One pneumonia | 27 [18.37%] | 8 [25%] | 18 [14.63%] | |
| Two pneumonias | 0 [0%] | 0 [0%] | 1 [0.81%] | |
| Pneumonia episodes requiring hospitalization over the year preceding vaccination | ||||
| None | 120 [81.63%] | 27 [84.38%] | 104 [84.55%] | 0.715 |
| One hospitalization with pneumonia | 27 [18.37%] | 5 [15.62%] | 18 [14.63%] | |
| Two hospitalizations with pneumonia | 0 [0%] | 0 [0%] | 1 [0.81%] | |
Continuous numeric values are shown as Median (interquantile range); categorical values are shown as absolute numbers and percentage of group size.
COPD chronic obstructive pulmonary disease, BMI body mass index, CAT COPD assessment test, MMRC Modified Medical Research Council dyspnea scale, 6MWT 6-min walk test, SGRQ St. George’s Respiratory Questionnaire.