Bevacizumab
Generic Name	Bevacizumab
Trade Name	Avastin
Company Name	Roche
Drug Type	Antibody
Drug Class	Angiogenesis ‐ VEGF
Dose	7.5 milligrams (mg) per kilogram (kg)
Route	IV
Schedule of Administration	Patients received bevacizumab 7.5 mg/kg on day 1 every 3 weeks
S‐1
Generic Name	S‐1
Trade Name	Tegafur, gimeracil, and oteracil potassium capsules
Company Name	Shandong New Time Pharmaceutical Co., Ltd.
Drug Type	Small molecule
Drug Class	Antimetabolite
Dose	BSA <1.25 m2, 80 mg/day; BSA ≥1.25 m2 but <1.5 m2, 100 mg/day; and BSA ≥1.5 m2, 120 mg/day; milligrams (mg) per flat dose milligrams (mg) per squared meter (m2)
Route	Oral (p.o.)
Schedule of Administration	Patients received S‐1 on days 1–14 every 3 weeks. Dose was based on BSA.
Raltitrexed
Generic Name	Raltitrexed
Trade Name	Raltitrexed
Company Name	Nanjing CHIA TAI Tianqing Pharmaceutical Co. Ltd.
Drug Type	Small molecule
Drug Class	Antimetabolite
Dose	3 milligrams (mg) per squared meter (m2)
Route	IV
Schedule of Administration	Patients received raltitrexed 3 mg/m2 on day 1 every 3 weeks