Generic/Working Name	Metatinib tromethamine tablet
Company Name	Jiangsu Simcere Pharmaceutical Co., Ltd
Drug Type	Small molecule
Drug Class	MET ‐ c‐MET
Dose	25–300 mg (tablets) per day milligrams (mg) per flat dose
Route	Oral (p.o.)
Schedule of Administration	All patients received escalating doses of metatinib tromethamine tablet with a single dose on day 1, then 2 days off, and then a multidose schedule, meaning once daily for 25 consecutive days (days 4–28). The single dose was administered orally 2 hours before the breakfast; in the multidose schedule, the daily dose was administered orally 1 hour before the breakfast and could be modified according to the following PK data. A standard 3 + 3 design was applied in this study, with terms of cohort expansion to six evaluable patients if a DLT was observed in the first cycle (days 1–32) in the initial three patients. If two DLTs were observed during the first cycle (days 1–32) in a cohort, dose escalation was stopped, and dosage continued at a lower level until the MTD was identified. The planned doses were 25, 50, 100, 200, 300, 450, 600, and 800 mg/day, respectively.