Table 1.

Buprenorphine Micro-dosing Protocol

Day of micro-dosing protocol (day of hospitalization)	Buprenorphine* dose	Methadone dose
1 (11)	0.5 mg SL once	20 mg daily
2 (12)	0.5 mg SL BID	20 mg daily
3 (13)	1 mg SL BID	20 mg daily
4 (14)	2 mg SL BID	20 mg daily
5 (15)	4 mg SL BID	20 mg daily
6 (16)	4 mg SL TID	20 mg daily
7 (17)	4 mg SL QID	Discontinued

*Our inpatient pharmacy primarily carries the buprenorphine mono-product (sublingual tablet). However, for doses of 0.5 mg and 1.0 mg, a combination buprenorphine/naloxone product (sublingual film) is used for practical ease of cutting the dose