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. 2021 Aug 5;11:15980. doi: 10.1038/s41598-021-95300-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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White matter tracts in the habit circuit. Views of the right (A), left (B) and bilateral (C) premotor/SMA (pink)-posterolateral putamen (green) tracts in an example healthy participant. (D) Mean volume of total bilateral premotor/SMA-putamen tracts was significantly higher in the adult AN group compared to the healthy controls (* indicates P < 0.05) and showed significant correlation with ritual behavior symptom severity (ritual subscale of the Yale-Brown-Cornell Eating Disorder Scale). (E) Compared to the healthy controls, the adult AN group shows a near significant higher bilateral tracts number. Moreover, the tracts number was found to have a significant correlation with ritual behavior symptom severity. (F) FA value in the bilateral premotor/SMA-putamen tracts was not found to be significantly different between AN and HC groups and did not show significant correlation with ritual behavior symptom severity.