Table 3.
Pivotal residues involved in conformational transition of caspase-6.
| Regions | Residues | Roles |
|---|---|---|
| 60′s helix/L1 | His52, Glu53, Arg54 | β-turn formation in 130′s extended helix |
| Pro62, Glu63, Arg64, Arg65 | Residue rearrangement in active site | |
| Thr67 | Structural reorganization of 60′s helix | |
| 90′s helix | Asp90, Leu91, Ala93 | Inward rotation in 90′s helix |
| 130′s helix/L3 | Tyr130, Asp131, Glu135 | Inward rotation in 90′s helix |
| Ser120, His121 | Residue rearrangement in active site | |
| Glu123, Asn125, His126, Tyr128, Lys133 | β-turn formation in 130′s extended helix |
Bold: Residues within 5 Å distance to the co-crystallized inhibitor Ac-VEID-CHO.