Table 2.
Body weights (g) of rats treated with Nexrutine in repeated dose toxicity study.
| Dose | Relative Organ Weight (g/100 body weight) |
||||
|---|---|---|---|---|---|
| Liver | Lungs | Kidney | Spleen | Heart | |
| Control | 4.8 ± 0.46 | 0.86 ± 0.08 | 0.82 ± 0.02 | 0.47 ± 0.08 | 0.39 ± 0.03 |
| 250 mg/kg | 4.3 ± 0.30 | 0.87 ± 0.21 | 0.74 ± 0.09 | 0.48 ± 0.10 | 0.36 ± 0.03 |
| 500 mg/kg | 4.2 ± 0.25 | 0.87 ± 0.06 | 0.75 ± 0.09 | 0.43 ± 0.08 | 0.35 ± 0.01 |
| 750 mg/kg | 4.06 ± 0.27 | 0.84 ± 0.11 | 0.65 ± 0.16 | 0.50 ± 0.14 | 0.53 ± 0.28 |
Data represent mean ± SD of five animals. Animals treated with 0.01 % CM cellulose serve as negative control and are comparable to untreated control group animals.