Table 3.
Effect of oral administration of Nexrutine on hematological parameter in Wistar rats.
| Parameter | Control | Nexrutine (mg/kg bw) |
||
|---|---|---|---|---|
| 250 | 500 | 750 | ||
| WBC | 18.90 ± 1.93 | 11.66 ± 8.00 | 15.99 ± 1.95 | 7.47 ± 3.9 |
| RBC | 8.34 ± 0.41 | 7.62 ± 0.44∗ | 7.54 ± 0.30∗ | 8.26 ± 0.23 |
| HGB | 15.10 ± 0.82 | 13.76 ± 0.52∗ | 13.88 ± 0.17∗ | 14.84 ± 0.66 |
| HCT | 45.35 ± 0.75 | 41.5 ± 1.56∗ | 41.75 ± 0.28∗ | 44.5 ± 1.49 |
| MCV | 54.4 0 ± 2.27 | 54.52 ± 2.22 | 55.4 ± 2.19 | 53.66 ± 1.84 |
| MCH | 18.08 ± 0.53 | 18.08 ± 0.55 | 18.4 ± 0.62 | 17.98 ± 0.77 |
| MCHC | 33.27 ± 1.32 | 33.18 ± 0.40 | 33.25 ± 0.35 | 33.36 ± 0.66 |
| RDW-SD | 30.08 ± 1.69 | 31.3 ± 0.71 | 31.57 ± 1.71 | 30.08 ± 0.88 |
| RDW-CV | 18.20 ± 0.31 | 17.48 ± 1.48 | 17.4 ± 1.81 | 17.66 ± 0.8 |
| PDW | 8.10 ± 0.29 | 8.02 ± 0.25 | 8.00 ± 0.53 | 8.04 ± 0.42 |
| MPV | 7.27 ± 0.15 | 7.32 ± 0.17 | 7.26 ± 0.40 | 7.26 ± 0.32 |
| P-LCR | 7.32 ± 1.38 | 7.48 ± 1.20 | 7.10 ± 2.32 | 7.22 ± 1.56 |
| PCT | 0.58 ± 0.01 | 0.50 ± 0.04 | 0.50 ± 0.01 | 0.45 ± 0.07 |
Data represent mean ± SD of five animals. Animals treated with 0.01 % CM cellulose serve as negative control and are comparable to untreated control group animals. ∗p < 0.05, significant with respect to control group.
Abbreviations- HGB- Hemoglobin; WBC-White blood cells; RBC- Red blood cell; HCT- Hematocrit; MCV- Mean corpuscular volume; MCH- Mean corpuscular hemoglobin; MCHC- Mean corpuscular hemoglobin concentration; RDW-SD- Red cell distribution width-standard deviation; RDW-CV- Red cell distribution width-coefficient of variation; PDW- Platelet distribution width; MPV- mean platelet volume; P-LCR- Platelet large cell ratio; PCT- Procalcitonin.