Table 1.
Medical history and clinical, histological, and molecular characteristics of the patient.
| History of primary diagnosis and medical history | |
|---|---|
| Gender, age | Female, 49 years |
| Staging of primary status | Primary pulmonary metastatic VAC |
| Tumor diameter: 4 cm with infiltration of the lateral pelvic side wall due to an additional tumor on the sacrotuberal ligament | |
| Multiple lung metastases up to 5 mm diameter | |
| Immunohistochemistry | Vimentin +8 |
| CK 7 + | |
| PR−, ER− | |
| p16− | |
| Ki-67: 70% | |
| ERBB2: Expression 60% | |
| PD-L1: CPS: 2, IC: 5, TPS: <1% | |
| MLH1, MSH2, MSH6, PMS2 stable | |
| Molecular profile | ARID1A Exon 20: c.5548dup (p.D1850fs) 5,1Mut/Mb |
| No genefusions | |
| Performance Status | ECOG 0 |
| Medical history | None, especially no history of DES exposure, endometriosis, or HPV infection |
| Family history | None |
| Psychological history | Married, 1 child |